It has been done only 45 times since 1987
If you sort by active players, these stats have been reached in a game only 18 times:
Dirk - 1
Amare - 1
Kobe, Vince and Wade - 2 each
TMac - 4
LeBron - 6
LeBron put up his 37/10/6/2/2 in 36 minutes, which was done before....one time, by Hakeem Olajuwon on April 6, 1993.
LeBron's current PER -- 46.2
LeBron led the league last year in PER at 27.3, and the highest full-season PER I can find is Wilt at 31.8, followed by Jordan and LeBron at 31.7. So yeah, pretty awesome game.